Effectiveness of Probiotic strains in Helicobacter pylori eradication from stomach

Effectiveness of Probiotic strains in Helicobacter pylori eradication from stomach naturally

In our earlier article natural ways in eradication of H. pylori we have discussed but not much about effectiveness of probiotics. Health beneficial roles of probiotics appear as myriad. Numerous studies have shown positive results in H. pylori eradication. However in most cases probiotics were used in combinations. Therefore I had few questions in my mind. As friendly microbes probiotics compete with pathogenic bacteria but how much it can exert its effect against H. Pylori. Can probiotics do alone or play a supportive roles. Therefore I decided to dig more. And here my finding in effectiveness of different Probiotic strains in Helicobacter pylori eradication from stomach naturally.

Previous related articles:

H. Pylori and the relationship with gastritis, peptic ulcers & symptoms

Best natural ways to eradicate H. pylori bacteria from your stomach

Natural scientifically proven home remedies to heal ulcer in stomach

Weak stomach acid and the hidden cause of acid reflux and heartburn

How long term acid suppression can cause iron deficiency anemia

How long term acid suppression can cause vitamin deficiency

Effectiveness of Probiotic strains in Helicobacter pylori eradication from stomach naturally

Mainly three probiotics strains have been identified against H. Pylori eradication in present.



Saccharomyces boulardii

Multi-strain formula

Lactobacillus Family

By producing urease H. pylori can save itself from stomach acid. In vitro Lactobacillus acidophilus may hamper H. pylori urease activity. Also lactobacilli produce lactic acid, which can counteract H. pylori-induced hypochlorhydria. (1) In combination Lactobacillus had shown significant result (2) However in mono therapy rate of eradication of Lactobacilli is weighted as 16%. Boonyaritichaikij et al found cheese with Lactobacillus gasseri for 12 month had shown 29.3% eradicate rate.(1) Francavilla R et al. found Lactobacillus reuteri inhibits H. pylori growth and significantly reduces in antibiotic-associated side effects when combines. (3)

Bifidobacterium Family

Bifidobacterium is one of the favorite microbiota used for the prevention of gastrointestinal infection, and it is commonly incorporated in fermented dairy products or food supplements. In vitro study Bifidobacterium exerts anti-H. pylori activity and compete with it and also inhibits adhesion to the gastric mucosa. (4) Study also found regular intake of of yogurt containing Lactobacillus and Bifidobacterium effectively suppressed H. pylori infection.(5)

Saccharomyces boulardii

Saccharomyces boulardii is not a bacteria, is a type of fungus sourced from the skin of plants such as lychee and mangosteen. S. boulardii is used treating and preventing in various gastrointestinal problems like diarrhea. The addition of S. boulardii significantly increased the eradication rate. However in mono therapy a pooled data analysis has given eradication weight-age as 16%.(1) Saccharomyces boulardii has a positive effect on reducing the colonization of H. pylori but has less capability on eradication when used as single therapy.(6)

Effectiveness of Probiotic strains in Helicobacter pylori eradication from stomach naturally

Multi-Strain Propoitics

Multi strain probiotics has showing better result than single strain. Rosania et al found multi-strain probiotics formula (S. termophilus, L. acidophilus, B. longum, L. plantarum, B. brevis, L. paracasei, B. infantis, L. delbrueckii) had shown 32.5% eradication rate after 4 weeks. (7)

Bottom Line

Probiotics had a positive effect on inhibiting of H pylori infection mediated inflammation. (2) Although probiotics have not showing as much as effective when used alone it supports other therapy in considerable extent. Probiotics also reduce adverse effect of drug like antibiotics. Also if you wish to support eradication rate of H. Pylori you need to check probiotics strains like Lactobacillus, Bifidobacterium, Saccharomyces boulardii. Although probiotics is very safe you should not use probiotics more specifically probiotics with Saccharomyces boulardii strain when you are critically ill.

Also read best natural way to eradicate H. pylori bacteria from your stomach.

Disclaimer: Information provided here are generalized information for 
educational purpose only,  not intended to provide one to one health 
consultation or replace practice of a qualified practitioner. Different 
people may have different health condition and may have different reaction 
to the same food. Hence it has been advised to consult with health care 
provider before application of any of above guidelines.
1. Giuseppe Losurdo, Rossella Cubisino, Michele Barone, Mariabeatrice 
Principi, Gioacchino Leandro, Enzo Ierardi, and  Alfredo Di Leo, Probiotic 
monotherapy and Helicobacter pylori eradication: A systematic review with 
pooled-data analysis,World J Gastroenterol. 2018 Jan 7; 24(1): 139–149  
2. Xiaoguang Shi et al., Efficacy and safety of probiotics in eradicating 
Helicobacter pylori, A network meta-analysis, Medicine (Baltimore). 2019 
Apr; 98(15): e15180 
3.Francavilla R et al,Lactobacillus reuteri strain combination in 
Helicobacter pylori infection: a randomized, double-blind, placebo-
controlled study,  J Clin Gastroenterol. 2014 May-Jun;48(5):407-13.   
4.Guadalupe Ayala, Wendy Itzel Escobedo-Hinojosa, Carlos Felipe de la Cruz-
Herrera, and  Irma Romero,  Exploring alternative treatments for 
Helicobacter pylori infection,  World J Gastroenterol. 2014 Feb 14; 20(6): 
5. Wang KY, Li SN, Liu CS, Perng DS, Su YC, Wu DC, Jan CM, Lai CH, Wang TN, 
Wang WM., Effects of ingesting Lactobacillus- and Bifidobacterium-
containing yogurt in subjects with colonized Helicobacter pylori,
Am J Clin Nutr. 2004 Sep;80(3):737-41
6.Kokab Namkin, Mahmood Zardast, and  Fatemeh Basirinejad,Saccharomyces 
Boulardii in Helicobacter Pylori Eradication in Children: A Randomized 
Trial From Iran,  Iran J Pediatr. 2016 Feb; 26(1): e3768 
7. Rosania R, Minenna MF, Giorgio F, Facciorusso A, De Francesco V, Hassan 
C, Panella C, Ierardi E.,Probiotic multistrain treatment may eradicate 
Helicobacter pylori  from the stomach of dyspeptics: a placebo-controlled 
pilot study, Inflamm Allergy Drug Targets. 2012 Jun;11(3):244-9         
Bikramjit Konwar

Author: Bikramjit Konwar


3 Responses

  1. Probiotics seem to be getting popularity. Nicely formulated, these preparations taste well and help in digestion. by populating helpful bacteria in the gut.

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