Amazing benefits of Pantethine to reduce cholesterol for heart health

Amazing benefits of Pantethine to reduce cholesterol for heart health

Pantethine is a metabolically active derivative of Pantothenic acid (also known as vitamin B5). But why I am talking about this form? Because Pantethine has shown significant health benefits to reduce cholesterol for heart health than other forms. With a number of ways, Pantethine can improve your serum cholesterol level. Let’s find.

Benefits of Pantethine to reduce cholesterol for heart health

Pantethine reduces oxidation of cholesterol

Probably you may hear about the oxidation of cholesterol. When serum cholesterol or lipid is oxidized it can lead to lipid deposition resulting in fatty streak formation in arteries. And such conditions further lead to the development of atherosclerosis or narrowing blood vessels. And pantetheine reduces LDL oxidation. (1,2,3)Thus pantetheine help to prevent fatty deposit in blood vessels.

Pantethine reduces serum cholesterol

Although cholesterol-lowering medication statin lowers LDL cholesterol, health risks of intensive prolonged use of statins include increased risk of developing diabetes, muscle and liver damage, and cognitive impairment.(4) Studies indicate that pantethine helps reduce cholesterol levels by dual mechanisms—reducing the rate of new cholesterol production as well as reducing existing cholesterol. On the other hand pantethine, a naturally occurring physiological compound synthesized in the body appears as safe and effective. In Japan, pantethine has been used for over 40 years. (4,5)

Benefits of Pantethine to reduce cholesterol for heart health

What researches have found?

More than 28 clinical trials have shown consistent and significant improvement in blood lipid or cholesterol profile. (3) Pantethine reduces serum LDL cholesterol as well as triglycerides. Apart from that pantethine also increases good cholesterol HDL. And in a review, the results found as (6)

  • The mean percentage of total cholesterol decreased from baseline as 8.7% after 1 month, 11.6% after 2 months, 12.6% after 3 months, and 15.1% after 4 months.
  • The mean percentage of LDL cholesterol decreased from baseline as 10.4% after 1 month, 15.2% after 2 months, 17.7% after 3 months, and 20.1% after 4 months.
  • On the other hand, the mean percentage of HDL or good cholesterol increased from baseline as 6.1% after 1 month, 7.8% after 2 months, 10.7% after 3 months, and 8.4% after 4 months.
  • The mean percentage of serum triglycerides decreased as 14.2% after 1 month, 15.8% after 2 months, 23.7% after 3 months, and 32.9% after 4 months.

However, LDL cholesterol is not that simple as bad cholesterol. Learn more about small dense LDL, large LDL, and particle number of ApoB in the development of heart disease. And know how the body stores excess calories from both glucose and fructose dramatically from simple sugar.

Related article:

What you should know to prevent heart disease

If you have high blood cholesterol then foods to lower high cholesterol naturally

Best foods to lower high blood pressure

Why vitamin K2 is so critical for your cardiovascular health to prevent arterial calcification.

How coenzyme Q10 helps in production of mitochondrial energy as well as improve heart health 

Tocotrienols form of vitamin E more specifically gamma and delta forms also have very powerful presence in management of cholesterol.

How to choose right cooking oil for your kitchen

Roles of omega 3 fatty acids for your heart as well as over all health


So what data we have about the safety of pantethine. Scientists found pantethine as effective non-toxic as well as well-tolerated in the management of serum cholesterol. (6) However, pantethine may slower blood clotting. Therefore if you have a bleeding disorder or are taking blood clotting medication you should consult your physician first. For the case of pregnancy and breastfeeding, there is no enough data.

Daily Dosage

The recommended effective dose is 300 mg thrice a day or 450 mg twice a day with or without food. (3) Apart from in management of lipid profile pantethine is also used in preventing inflammation, boosting the activity of the immune system, for gastrointestinal diseases as well as improving athletic performance and others. (7)

Disclaimer: Information provided here are generalized information 
for educational purpose only,  not intended to provide medical 
advice or one to one health consultation or replace practice of a 
qualified practitioner. Different people may have different 
health condition and may have different reaction to the same 
food. Hence it has been advised to consult with health care 
provider before application of any of above guidelines.
1.Bon GB, Cazzolato G, Zago S, Avogaro P.,  Effects of 
pantethine on in-vitro peroxidation of low density lipoproteins, 
Atherosclerosis. 1985 Oct;57(1):99-106  
2.Zoltan Horvath and Laszlo ́Vecsei,Treatment With Pantethine,  
Journal of Evidence-Based Complementary & Alternative 
Medicine,16(1) 21-28,2011  
3.Mark Houston,The Role of Nutraceutical Supplements in the 
Treatment of Dyslipidemia,The Journal of Clinical Hypertension,  
Volume 14, Issue 2 February 2012
4.Malkanthi Evans, John A Rumberger, Isao Azumano, Joseph J 
Napolitano, Danielle Citrolo, and  Toshikazu Kamiya, Pantethine, 
a derivative of vitamin B5,  favorably alters total, LDL and non-
HDL cholesterol in low to moderate  cardiovascular risk subjects 
eligible for statin therapy: a triple-blinded placebo and diet-
controlled investigation,  Vasc Health Risk Manag. 2014; 10: 89–
5.Mark Houston,  Dyslipidemia,Integrative Medicine (Fourth 
Edition), 2018
6. MP McRae,Treatment of hyperlipoproteinemia with pantethine: a 
review and analysis of efficacy and tolerability, Nutr Res.  
2005; 25: 319– 333 
Bikramjit Konwar

Author: Bikramjit Konwar


2 Responses

  1. Interesting article. It will be important to know how much does pathethine reduce risk of heart attack and improve life expectancy over a long period of time.

    1. Pantethine reduces lipid oxidation and lipid deposition in artery that is one major risk factor of heart disease. Only oxidized LDL-C is deposited in artery not native cholesterol.Although abnormal serum LDL-C may not a desirable condition question arises when elderly people with high LDL-C live as long or longer than those with low LDL-C. ( )Uffe Ravnskov born in 1934 is a Danish doctor a long time independent researcher writer of The Cholesterol Myths. If you don’t eat your body will make cholesterol. Development of heart disease is multi factorial not depend on single factor. I have also mentioned some relevant articles here and will in with coming articles. In general long term life expectancy is evaluated in corhot study where other factors also play well. In my knowledge life isolated life expectancy is not evaluated for pantethine. Jonny Bowden, a nutrition specialist, Stephen T. Sinatra,a board-certified cardiologist specializing in integrative medicine, Deirdre Rawlings, ND explained well about cholesterol in their book The Great Cholesterol Myth

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